By T.W. Gullikson and C.E. Calverley
Summary: In 1922 researchers at the University of California at Berkeley showed that rats deprived of an unidentified substance found in leafy greens and wheat germ failed to reproduce. The fat-soluble nutrient was named vitamin E, and soon research groups around the world were studying the effects of its deficiency in species ranging from turkeys to the tree-kangaroo. In this 1946 report, researchers at the Minnesota Agricultural Station reveal the surprising results of a ten-year investigation into the effects of vitamin E deficiency on the reproductive health of cows. While the animals were able to reproduce, many of them suffered another, unforeseen calamity: sudden, fatal heart failure. Meanwhile, clinicians were reporting a variety of successful applications of vitamin E therapy in humans, as epitomized by the famous Shute brothers, two Canadian doctors who documented the effective use of vitamin E in nearly ten thousand heart patients—results discredited and ignored by the medical community to this day. From Science, 1946. Reprinted by the Lee Foundation for Nutritional Research.