By W.J. McCormick, MD
Summary: A Canadian medical doctor recounts the history of scurvy and its prevention, including a fascinating report by British medical officer James Lind, who describes his famous experiment of 1747 in which he cured sailors of the disease by feeding them fresh oranges and lemons. While full-blown scurvy had been virtually eliminated in twentieth-century America thanks to the widespread availability of citrus fruits, Dr. McCormick makes the case that subclinical vitamin C deficiency was a causative factor in many modern disorders, including rheumatoid arthritis, heart attack, cancer, pneumonia, and even stretch marks in birthing mothers. Failure to recognize the tissue dysfunction in these disorders to be the result of vitamin C deficiency has led medicine to devise countless unsuccessful approaches to what appear to be largely matters of starvation. From Journal of Applied Nutrition, 1962. Lee Foundation for Nutritional Research reprint 5H.
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Have We Forgotten the Lesson of Scurvy?
Can the Recorded Knowledge of This Disease Aid in the Solution of Our Modern Disease Problems?[spacer height=”20px”]
From the fourteenth to the nineteenth century, scurvy took the lives of millions annually in Europe and Asia. From 1600 to 1800, it is estimated that fully a million English sailors succumbed to this disease. In the early history of these pandemics, the designations “Plague” and “Black Death” were used, but from a study of the diseases’ characteristic symptoms—multiple hemorrhages under the skin (red, purple, and black spots and hematoma) and from all mucous membranes (gastrointestinal, pulmonary, and genitourinary); and intramuscular and subperitoneal as well as subperiosteal effusions and cartilaginous disintegration in general—it may be assumed that these designations, for lack of better terminology, may be used interchangeably. At any rate there have been no pestilences of this nature since Lind, a Scottish surgeon, found the cause and cure of this disease over 200 years ago.
James Lind, a medical officer of the British navy, made this epochal discovery in 1747, aboard H.M.S. Salisbury at sea, when he made trial of a half dozen or more popularly recommended treatments, which he reported as follows:
“I took twelve patients in scurvy on board the Salisbury. They lay together in one place in the fore hold and had one, common diet: water gruel, sweetened with sugar, in the morning; fresh mutton broth oftentimes for dinner; and for supper barley and raisins, rice and currants, sago and wine, or the like.
“Two of these [patients] were ordered each a quart of cider per day. Two others took 25 gutts [drops] of elixir vitriol three times daily on an empty stomach. Two others took two spoonfuls of vinegar thrice daily on an empty stomach. Two of the worst patients were put on a course of seawater, of which they drank one half pint daily. Two others had each two oranges and one lemon given them every day; these they ate with greediness, at different times, on an empty stomach. They continued but six days under this course, having consumed the quantity that could be spared. The two remaining patients took the bigness of a nutmeg thrice daily and of an electuary recommended by a hospital surgeon, made of garlic, mustard seed, horseradish, balsam of Peru, and gum myrrh…
“The consequence was that most sudden and visible good effects were perceived from the use of the oranges and lemons, one of those who had taken them being at the end of six days fit for duty…The other was the best recovered of any in his condition, and being now deemed pretty well, was appointed nurse to the rest of the sick.”31
Dr. Lind, like many other researchers, did not live to see his discovery given general acceptance. He died in 1794, and in the following year, the British Admiralty made provision for a daily ration of lime or lemon juice to be given all sailors in the navy, and in consequence, even to this day, the sailors of the British navy are dubbed “limies.” During the time between this discovery and its practical application (forty-four years), nearly 200,000 British sailors died needlessly of scurvy.
The postmortem findings of Lind and his contemporaries are most revealing. Lind reports that he found the muscles of scurvy victims so lax and tender that they readily fell apart— the intestinal musculature the same—and he comments: “Why the scurvy should so frequently and in so singular manner affect the cartilage of the ribs, so as sometimes to separate them altogether from their connection to the breast bone…I own I am at a loss to account for.”18 He also reported a number of scurvy cases in which old fracture calluses and old scar tissue were broken down. He cites Martini (1609) as stating that “scurvy is nearly allied to the Plague, as it occasions carbuncles, buboes, and cancer.”
Willis, the great English anatomist, relates in his Tractus de Scorbuto, “A crackling of the bones upon moving the joints—even upon turning in bed—by rubbing of the vertebra upon each other…like to the rough handling of a skeleton.” Poupart, the great French surgeon, in reporting his findings in Paris scurvy victims, states:
“In some, when moved, we heard a small grating of the bones. Upon opening their cadavers, the epiphyses were found entirely separated from the bones, which by rubbing against each other had occasioned this noise. In some we heard during life a small, low noise when they breathed. In these (postmortem) the cartilages of the sternum were found separated from the bony part of the ribs…The ligaments of the joints were found corroded and loose…All the young persons under eighteen had in some degree their epiphyses separated from the body of the bones.”32
After the discovery and isolation of vitamin C in 1928 and the establishment of its causal relationship to scurvy, the declining incidence of this disease has led to complacency, scurvy being thought of as a well-nigh extinct disease. This has resulted in failure to recognize and treat subclinical forms of this disease and its complicating relationship to many other diseases.
Subclinical Scurvy in Obstetrics
In 1948, in a paper of mine, “The Striae of Pregnancy: A New Etiological Concept,”1 we reported clinical and laboratory findings in support of the thesis that these disfiguring subdermal lesions, which for centuries were regarded as a natural sequence of pregnancy, are the result of increased fragility of the involved abdominal connective tissue, secondary to deficiency of vitamin C. We quote from the summary as follows:
“The literature relative to the striae of pregnancy is reviewed, and Crede’s classical treatise is cited as most complete. All authors seem to agree that the striae are produced by rapid and extensive stretching of the skin and underlying connective tissues in the presence of decreased elasticity of the same. None, however, has elicited the specific factor causing this lack of elasticity.”
Based on the recently established knowledge that deficiency of vitamin C is conducive to decrease in tensile strength of tissues generally,2,3 the hypothesis that C-hypovitaminosis is the culpable etiological factor in striae gravidarum is advanced. It is intimated that other obstetrical complications involving the tensile strength and elasticity of tissue—including cervical and perineal laceration, abdominal hernia, rupture of the uterus, and hemorrhage (pre- and postpartum)—may also be similarly related.
Clinical data regarding the correlation in the incidence of the striae and the plasma ascorbic acid level in a series of twenty-six gravid women are presented. In general it was found that the degree of striation was inversely proportionate to the ascorbic acid level. Although the majority of the subjects were multiparous, 50 percent of the series were found to be free from striation. Ninety years ago, according to Crede, only 10 percent of gravid women were exempt from striae. We attribute this marked reduction in incidence to the increased consumption of citrus and other fruits of high vitamin C content within the last century.
Subclinical Scurvy and the Rheumatic Diseases
Lind cites Sennerti (1624), who, writing on scurvy, states: “In some, though more rarely on each motion of their joints, a noise was heard, as from broken bones or like the crackling of nuts [crepitus].” This is suggestive of our modern arthritic lesions. Engaleno, also cited by Lind, states that “gout is known to proceed from scurvy—by not being fixed but shifting from one joint to another and its being quickly cured by antiscorbutics.”18 Harvy, also cited by Lind, divides scurvy into three kinds: mouth scurvy, leg scurvy, and joint scurvy.
If such articular lesions were found in times past in frank scurvy cases, it is only logical to conclude that similar lesions of lesser degree, such as we now find in chronic rheumatic disease, may be etiologically related to deficiency of vitamin C. Our modern knowledge of this vitamin may thus provide the linkage between scurvy and these diseases.
James Rinehart and Stacy Mettier4 were the first modern writers to correlate deficiency of vitamin C with rheumatic disease. In animal experiments they found that prolonged deficiency of this vitamin in the diet produced functional impairment and anatomic changes in the joints. Throughout this research the concurrence of infection, superimposed on vitamin C deficiency, is stressed as being jointly involved in rheumatic etiology. The writer of this thesis adopts a modification of this concept in regarding both the infections and the arthritic phenomena as the sequelae of vitamin C deficiency.
Recently the author of this thesis has made therapeutic trial of massive doses of vitamin C (1 to 10 grams daily), intravenously and orally, in a number of cases of rheumatic fever. The patients made rapid and complete recovery in three to four weeks, without cardiac complications. Similarly favorable results have been obtained in incipient arthritis. We therefore believe that the rheumatic diseases should no longer be regarded as of unknown etiology.
Subclinical Scurvy and Intervertebral Disc Lesions
Our knowledge of the pathology of the intervertebral discs has been developed mostly within the last three decades. It is more than likely that lesions of these structures were equally if not more prevalent in earlier times but were not generally recognized until X-ray technique became a major factor in physical examination.
The possibility of preconditioning factors, in the form of degenerative changes, has been intimated by most writers, but the exact nature or cause of such changes has not been established. According to Beedle,5 “It is submitted as the most probable theory that certain faults in the texture of the cartilage matrix occur…and give rise to the rupture of the cartilage by minute traumatic influences that would have no effect on normal tissue.”
As degenerative changes advance in the disc structure, the elasticity of the same lessens; this loss of function is sometimes hastened by deposition of calcium, and the efficiency of the confining fibroelastic network is lost. When the stage of rupture and herniation is reached, the resultant lacerations are often accompanied by extensive hemorrhages, which further complicate the picture. That these lesions are not due to senile degenerative changes is shown by the age incidence: beginning in the second decade, it reaches its peak in the fourth, after which it gradually declines. Key6 has reported intervertebral disc lesions in young children and adolescents.
From a carefully correlated study of the nutritional background of subjects of these lesions and from the records of analogous postmortem findings regarding the condition of cartilaginous structures in scurvy, as cited by Lind in his treatise on this subject (1753), we are convinced that deficiency of vitamin C plays an important role in the etiology of these lesions, as well as in those of the semilunar cartilages of the knees, the sacroiliac synchondroses, etc. It seems obvious therefore that therapeutic use of the vitamin should be made as part of the nonsurgical care of all such cases. It is conceivable that such means might result in fixation of a slipping disc or cartilage and prevent rupture or herniation of same. “A stitch in time saves nine.”
Subclinical Scurvy and Pneumonia
In 1936 Gander and Niederberger7 found that vitamin C favorably influenced the course of pneumonia. When the vitamin C status was brought up to normal saturation level early in the disease, the temperature dropped abruptly to normal, and the pain subsided. The pulse remained of good tone, and remarkable general improvement was made. In the same year, Hochwald8 independently reported similar results, his findings indicating that massive doses of vitamin C—500 mg every ninety minutes until the temperature drops to normal—exerted a curative effect in croupous pneumonia, as shown by lessened prostration and dyspnea and earlier return to normal temperature and to normal white blood cell picture.
More recently the author of this treatise had occasion to treat a case of bilateral pneumonia in a middle-aged man. The temperature was 104 [Fahrenheit], and both lungs were almost filled with exudate. Treatment was begun with 1000 mg vitamin C intravenously, followed by 500 mg orally, with a half glass of orange juice, every hour. On second call, seven hours later, the intravenous injection was repeated. At that time the temperature was nearly normal. This same treatment was continued for three days, by which time the pulmonary exudate had practically cleared. On the fourth day, the patient felt so well that he voluntarily resumed work, with no adverse effects.
In 1944 Slotkin and Fletcher9 reported on the prophylactic and therapeutic value of vitamin C in postoperative pneumonia. They summarized their findings as follows:
“Pulmonary complications in old, debilitated patients requiring prostatic surgery is a common cause of death. The pulmonary lesions most noticed were bronchopneumonia, lung abscess, and purulent bronchitis. Most of these cases are ‘wet chest,’ due to capillary secretions. Vitamin C, which increases the tonicity of these capillaries, has greatly alleviated this condition and promptly restored normal pulmonary function.”
Slotkin10 further reports that since publication of his paper on this subject, “Vitamin C has been used routinely by the general surgeons in the Millard Fillmore Hospital, Buffalo, as a prophylactic against pneumonia, with complete disappearance of this complication.” Terminal pneumonia is often the cause of death in frank scurvy, and the “rusty-brown” sputum of pneumonia may owe its origin to the hemorrhagic status of subclinical scurvy.
Subclinical Scurvy and Tuberculosis
Tuberculosis has long been clinically related to scurvy and vitamin C deficiency, and it has been favorably influenced by concurrent vitamin C therapy. Richard Morton, one of the earliest writers on this disease, says in his famous Phthisiologia (1689): “Scurvy is wont to occasion a consumption of the lungs.”
Harris11 finds that the excretion of vitamin C is decreased in tuberculosis, that this deficiency reduces the resistance of guinea pigs in tuberculosis, and that similar effects have been observed in man. Bauer and Vorwerk12 report vitamin C deficiencies of from 1 to 4 grams in tuberculosis cases. They state that there seems to be certain parallelism between the activity of tuberculosis and the extent of vitamin C deficiency. McConkey13 reports that of 437 pulmonary cases admitted to a New York State hospital for tuberculosis in 1926 and 1927, forty-seven developed intestinal tuberculosis, whereas, of 399 admitted in 1928 and 1929, who received a prophylactic treatment consisting of 3 oz of citrus or tomato juice and 3 oz of cod liver oil with each meal, only three developed intestinal tuberculosis. Furthermore, of 913 other patients admitted during 1930 to 1938, who received the same prophylactic treatment, only nine developed intestinal tuberculosis.
Borsalino14 reports a study of 140 tuberculosis patients in which administration of vitamin C rapidly increased capillary resistance and stopped hemotysis, which reappeared when the treatment was discontinued. Moore et al.,15 in a recent survey of nutrition among the northern Manitoba Indians, report a very high mortality rate from tuberculosis and pneumonia (761 and 383, respectively, per 100,000). In the tribes covered by their study, the death rate for tuberculosis in 1942 was 1400 per 100,000. The figures for the white population of Manitoba at that time was 27 per 100,000. The daily per capita food intake they found most deficient in vitamin C—less than 1/71 of the recommended allowance. In conclusion they say, “It is not unlikely that the Indian’s great susceptibility to many diseases, paramount amongst which is tuberculosis, may be attributable to their high degree of malnutrition.”
Subclinical Scurvy and Coronary Thrombosis
Coronary thrombosis first made its appearance in our vital statistics about fifty-years ago. Since that time its incidence has steadily increased, and now it heads our mortality list in the vascular disease group and tops our mortality figures generally. The major clinical feature of this disease is the development of a thrombus on the intima of the coronary artery at a point of threatened breach that gradually builds up until, in the course of weeks, months, or years, it occludes the lumen of the artery. As this state approaches, the patient suffers heart pains and shortness of breath, and in many cases it culminates in a fatal seizure.
Paterson,16 of the Ottawa Civic Hospital, in a series of autopsies on coronary cases, frequently found a capillary hemorrhage at the site of the thrombosis, which he regarded as an etiological prelude resulting from deficiency of vitamin C. In support of this conclusion, he found that 81 percent of his coronary cases had a subnormal level of vitamin C, compared with 55 percent in a corresponding group of general public ward cases. Accordingly, he suggested that coronary patients be assured of an adequate intake of this vitamin. Willis17 has shown that scurvy (or extreme deficiency of vitamin C) in guinea pigs is prone to cause thrombotic lesions identical to those of the human disease.
Subclinical Scurvy and Cancer
As long ago as 1609, Martini (cited by Lind) stated that scurvy is nearly allied to the Plague, as it occasions carbuncles, buboes, and cancer. In an effort to clarify this relationship, we published two papers18 in which we advanced the hypothesis that deficiency of vitamin C—by bringing about disintegration of epithelial and connective tissue relationships, owing to liquefaction19 of the intercellular cement substance (collagen) and disintegration of the connective tissue of the basement membrane—results in breakdown of orderly cellular arrangement, thus acting as a prelude to cancer.
Pirani and Catchpole20 found that glycoprotein (collagen) thus liberated finds its way into the bloodstream, resulting in an increased serum level. Wollbach21 found that administration of vitamin C in scurvy rapidly restores the normal consistency of collagen. Simkin et al.22 report an increase of serum glycoprotein (collagen) in cancer. Studies by Wingler (1953), Greenspan (1954), Locky et al. (1956), and Lansing (1957) have confirmed this finding. A correlation of these findings gives support to our hypothesis. As further evidence, a diagnostic test for cancer has been developed in Germany (the Whitting reaction) based on the blood-protein picture.23
Schneider24 cites Eickhorn as finding a pronounced deficiency of vitamin C in cancer case—averaging 4,550 mg by the saturation method while his noncancerous controls averaged only 1,350 mg. Bodansky et al.25 studied the vitamin C level of blood plasma and white blood cells in cancer cases compared with [those values in] noncancerous cases. The researchers found the levels in the former to be significantly lower. Russell et al.26 report that recurrent periods of scurvy, interspersed with periods of lettuce supplementation to prevent death, resulted in a significant shortening in the time of appearance of induced cancer in guinea pigs.
In accordance with these observations, may it not be maintained that the degree of malignancy in cancer is inversely proportionate to the degree of connective tissue resistance, which in turn is dependent on the adequacy of the vitamin C status? Scirrhous cancer of the breast is slow to metastasize and may remain inactive for many years; whereas the medullary (soft) cancer of the breast is extremely invasive. In the former there is predominant connective tissue stroma—which cohesively binds the cells effectively, thus curbing metastasis—while in the latter the structure is mainly cellular and almost completely lacking in connective tissue binder, thus favoring metastasis.
This variation in invasiveness is usually attributed to some intrinsic property of the cancer cells, but our hypothesis relates it to the acquired connective tissue resistance of the host. In other words, cancer is a disease that we unwittingly cultivate or contract by perverse habits of life. The wise man Solomon said, “The curse causeless shall not come” (Proverbs 26:2). Ravdin, I.S., has said: “While surgery and radiology are helpful, they do not attack the underlying biological defects…Sometime, someplace, the existing jigsaw puzzle will be properly put together, and we shall wonder why the correct answer evaded us for so long a time.”27
The implications from these observations strongly suggest that our major effort should be directed toward prevention of the cause of the cellular disarrangement—collagenous breakdown of epithelial and subepithelial connective tissues, as manifested in open sores or fissures that fail to heal readily and unusual or easily produced hemorrhage. Such lesions may be early warning signs of future cancer. They likewise are early signs of scurvy. Advance indications of such conditions may be noted in female subjects who bruise easily, as shown by unaccountable “black and blue” spots. We have found that fully 90 percent of our adult female population are so afflicted and by chemical test are found to be deficient in vitamin C.
Our observations in this respect have led us to the conclusion that the major cause of vitamin C deficiency in our modern civilization may be the well-nigh universal tobacco addiction. The smoking habit not only militates against normal nutritional practice, but it actually neutralizes or destroys to a great extent what little vitamin C is taken in in food. In checking the vitamin C requirements of subjects who smoke and who do not smoke, we have found, by clinical and laboratory means, that the smoking of one cigarette, as ordinarily inhaled, tends to neutralize in the body about 25 mg of the vitamin—or that amount contained in an ordinary orange.28
This reciprocal effect is due, we think, to the chemical action of ascorbic acid as an oxidizing or reducing agent. Our findings in this respect have been confirmed by independent research in USA29 and in Europe. On the basis of our hypothesis, these findings would help explain the phenomenal increase in lung cancer and the current upsurge in the incidence of leukemia in newborn infants and young children, which we have dealt with in a recent treatise.30
In further support of this new concept of etiology, we cite Dr. Felix Pincus, of Germany, on the subject “Acute Lymphatic Leukemia” in Nothnagel’s Encyclopedia of Practical Medicine (American Edition, W.B. Saunders and Co., Philadelphia, 1905, subsection “Acute Lymphatic Leukemia,” pages 552–574):
“The most striking clinical symptoms of this disease are the hemorrhages and their sequelae. We refer especially to hemorrhages into the skin, the invisible mucous membranes, and the posterior eye ground and, further, the hemorrhages in the interior of the body—those that are recognizable during life by their clinical results, as of the intestine, the bladder, the brain, and the labyrinth of the ear.
“Sometimes large and deep necroses of the skin arise, which spread rapidly and show not the least tendency to heal. The teeth sit loosely imbedded in the spongy remains of the mucous membrane. Every touch produces hemorrhage, making a condition completely identical with that of scurvy. Especially interesting in this regard is the case of acute leukemia in a seventeen-year-old girl who never, or at most rarely, ate fresh vegetables—a deficiency always named among the primary causes of scurvy.”
This close linkage with scurvy seems to have been completely overlooked by modern writers on leukemia, the major stress being given to genetic changes in chromosomes, irrespective of possible adverse maternal contributory factors. Ingalls (1956) has this to say:
“Congenital defects are not all determined at the moment of conception; many are acquired during the ensuing fetal development. The latter are usually fetal manifestations of critical stress on the mother during pregnancy. Just as the genetically determined defects have been studied in the fruit fly by breeding experiments, so the acquired defects have been studied in the gravid mouse by the use of hypoxia (lack of oxygen) as a standard stress applied to the mother. A large class of congenital defects is therefore preventable.”
This new theory of the relationship of vitamin C deficiency in carcinogenesis suggests the possibility that all physical and chemical carcinogens may act indirectly by bringing about or exaggerating a latent deficiency of this vitamin. A comparable situation has prevailed regarding alcohol. For many years it was thought that alcohol was the specific cause of peripheral neuritis in the alcoholic subject, but it is now known that deficiency of vitamin B1 is the cause, the alcohol only increasing the requirement of the vitamin.
Conclusions
In conclusion it would seem that an optimal body level of vitamin C offers the best natural means of assuring healthy connective tissue and building natural resistance against any and all the diseases referred to in this treatise.
By W.J. McCormick, MD, Toronto, Canada. Reprinted by the Lee Foundation for Nutritional Research from the Journal of Applied Nutrition, 1962, Volume 15, Numbers 1 and 2, pages 4–12.
References
1. McCormick, W.J. “The Striae of Pregnancy: A New Etiological Concept.” Med. Record, August 1948.
2. Lanman and Ingalls. “Vitamin C Deficiency and Wound Healing.” Ann. Surg., 105: 616, 1937.
3. Taffel and Harvey. “Effect of Vitamin C Deficiency on Healing of Wounds.” Proc. Soc. Exper. Biol. and Med., 38: 518, 1938.
4. Rinehart, J.F., and Mettier, S. “Pathological Similarities Between Experimental Scurvy and Rheumatic Fever.” J. Exper. Med., 59: 97, 1934.
5. Beadle, O.A. Medical Research Council, Special Report Series, No. 161, 1931.
6. Key, J.A. “Intervertebral Disc Lesions in Children and Adolescents.” J. Bone and Joint Surg., 32A: 97, 1950.
7. Gander and Niederberger. “Vitamin C in the Handling of Pneumonia.” Munch. Med. Wchnschr., 31: 2074, 1956.
8. Hochwald, A. “Beobachtunger fiber Ascorbinsaure Wirkung bei der Krupposen Pneumonia.” Wien. Arch. f. inn. Med., 353, 1936.
9. Slotkin and Fletcher. “Ascorbic Acid in Pulmonary Complications Following Prostatic Surgery.” Jour. Urol., 52: Nov. 6, 1944.
10. Slotkin, G.E. Personal communication with the author. December 2, 1946.
11. Harris, L.J. “Nutrition and Its Effects on Infectious Diseases.” Lancet, 1: 811, 1937.
12. Baur and Vorwerk. “Beitrag sum Vitamin C Deficit bei Lungentuberculosen.” Beitr. S. Tuberk., 91: 262, 1938.
13. McConkey, M. “Cod Liver Oil and Tomato Juice in the Prophylaxis of Intestinal Tuberculosis.” Am. Review of Tuberculosis, 45: 425, 1941.
14. Borsalino, G. “Fragilite Capillare nella Tuberculose Polmonare e le sue Modificazione par azione della vitamin C.” Gior. de clin. Med., 18: 273, 1931.
15. Moore et al. “Nutrition Among Northern Manitoba Indians.” Can. Med. Assoc. J., 54: 223, 1946.
16. Paterson, J.C. “Some Factors in the Causation of Intimal Hemorrhage and in the Precipitation of Coronary Thrombosis.” C.M.A. Journal, 44: 114, 1941.
17. Willis, G.C. Report at annual meeting. RCPS [Royal College of Physicians and Surgeons] of Canada, Oct. 30, 1953.
18. McCormick, W.J. “Cancer: The Preconditioning Factor in Pathogenesis.” Arch. Ped., 71: 29, 1954; McCormick, W.J. “Cancer: A Collagen Disease Secondary to a Nutritional Deficiency?” Arch. Ped., 76: 166, 1959; McCormick, W.J. “Intervertebral Disc Lesions: A New Etiologic Concept.” Arch. Ped., 71: 29, 1954; McCormick, W.J. “The Rheumatic Diseases—Is There a Common Etiology?” Arch. Ped., 72: 107, 1955; McCormick, W.J. “Coronary Thrombosis: A New Concept of Mechanism and Etiology.” Clin. Med., 4: No. 7, 1957.
19. Wollbach, S.B., and Howe. “Liquefaction of Collagen in Scurvy.” Arch. Path. and Lab. Med., 69: 94, 1929.
20. Pirani, C.L., and Catchpole, H.R. “Serum Glycoprotein in Experimental Study.” Arch. Path., 51: 597, 1951.
21. Wollbach, S.B. “Administration of Ascorbic Acid in Scurvy Restores the Normal Consistence of Collagen.” Am. J. Path., 9: 689, 1923.
22. Simkin et al. “An Increase in Serum-Glycoprotein Is Found in Cancer.” Am. J. Med., 6: 734, 1951.
23. Heinerman, E. “A Diagnostic Test for Cancer, the Whitting Reaction, Based on the Blood-Protein Picture.” Med. Monatschr., 425, 1955.
24. Schneider, E. Deutsche Med. Wchnschr., 79: 15, 1954. Author cites Eickhorn as finding pronounced deficiency of vitamin C in cancer cases.
25. Bodansky, O. Cancer Research, 11: 238, 1951. In a study of the ascorbic acid level in the blood plasma and white-blood cells of cancerous and noncancerous subjects, author found that of the former significantly lower.
26. Russel et al. Cancer Research, 12: 216, 1952.
27. Ravdin, I.S. Annals of Surg., 142: 765, 1955.
28. McCormick, W.J. Archives Pediat. (NY), 69: 151, 1952.
29. Bonquin, A., and Masmanno. Am. J. Digest. Diseases, 20: 75, 1953.
30. McCormick, W.J. “Leukemia in Infants and Young Children: A New Etiological Concept.” Journal of Applied Nutrition, Vol. 14, No. 1-2: 95–98, 1961.
31. Lind, James. Treatise on the Scurvy. Edinborough, 1753.
32. Poupart, Francois. “Etranges effets du Scorbut arrivez a Paris par M. Poupart.” Memoires de l’Academie des Sciences, p. 237, 1699.
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